Plasma concentrations of diazepam and desmethyldiazepam during chronic diazepam therapy.
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چکیده
منابع مشابه
Phenytoin intoxication during concurrent diazepam therapy.
Phenytoin elimination is a saturable process obeying Michaelis-Menten kinetics. Plasma phenytoin levels are not related linearly to dose, and small changes in enzyme activity produced by concurrent drug therapy could alter plasma levels. Two cases of phenytoin intoxication associated with simultaneous administration of diazepam are reported. Intravenous phenytoin infusions were given and the ap...
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Patients who undergo cardiac catheterization are frequently taking propranolol and are often premedicated with diazepam. Because the intensity of a drug's action is determined by free, or non-protein-bound, levels in plasma, changes in the degree of protein binding may profoundly alter the pharmacologic effect. We examined the effects of heparin on the free levels of propranolol and diazepam in...
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Diazepam 1 mg/kg body weight was administered rectally to 14 children (11-22.5 kg) before minor surgery under general anaesthesia. Administration in solution (n = 7) resulted in a rapid increase in serum concentrations which were maintained for 8 h. Administration by suppository (n = 7) resulted in significantly lower serum concentrations at 10 and 20 min, but higher concentrations at 2 h. At o...
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Sir,—It is regretted that the interesting paper by Korttila and Tarkkanen (1985) does not state which preparation of diazepam they used. The early relative potency studies of midazolam and diazepam were undertaken with the organic solvent preparation, Valium. A review (Dundee et al., 1984) of these puts the relative potency of the two drugs at about 1.5:2.1:1. However, if Korttila and Tarkkanen...
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Ketamine causes cardiovascular stimulation, presumably, by increasing central sympathetic activity. This study was undertaken to find out if diazepam in appropriate doses could abolish or moderate the central sympathetic and cardiovascular stimulation following ketamine in patients undergoing cardiac surgery. Twelve patients, scheduled for valvular replacement (8) and direct aortocoronary bypas...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1978
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1978.tb01684.x